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Department
Department of Microbiology, Tumor and Cell Biology |
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Area of responsibilities/description of the work
Research in G Selivanova’s lab is focused on the identification and studies of the mechanism of action of small molecules restoring the tumor suppression functions of p53, either by refolding mutant p53 to rescue its activity, or via preventing proteasomal degradation of p53 in tumors with non-mutated p53 (Bykov et al, Nature Medicine, 8(3);282, 2002; Issaeva et al, Nature Medicine 10(12):3121, 2004; Enge et al, Cancer Cell 15(3):171, 2009; Grinkevich et al, Cancer Cell 15(5):441, 2009). To address fundamental questions of p53 biology, the lab uses small molecules as research tools and applies systems biology and high throughput assays, such as transcriptome profiling, ChIP-seq, and shRNA screens.
We are seeking two highly motivated and dedicated postdoctoral researchers to carry out an exciting endeavor aiming to develop novel strategies for improved targeted treatment. We invite two persons to work on the elucidation of the mechanism of action of small molecules, as well as novel p53-regulators which we identified and their validation using siRNA screens, biochemical. molecular biology and cellular assays, as well as clinical material and animal models. |
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Qualifications
A person is eligible for a postdoc position if he or she has obtained a PhD no more than five years before the last date of employment as postdoc.
To qualify, the applicant must hold a Ph.D degree or a foreign qualification deemed equivalent to a doctorate, preferably in cancer cell biology. The applicant must have more than 4 years of experience in molecular and cell biology, but less than 10 years in full-time research.
The employment as Postdoctoral Research Fellow will be fixed to two years, with possible continuation for two more years. The successful applicant should have experience with mammalian tissue culture techniques and molecular biology including DNA and RNA techniques, as well as biochemical methods. Preferred experience also includes immunoprecipitation, Western blot analysis, fluorescence microscopy, and flow cytomerty. Experience with high throughput methods, including transcriptomics and proteomics and/or bioinformatics is a plus. Solid experience and excellent track record from leading laboratories in the research field will be considered a distinct advantage.
Assessment grounds
Applicants will be evaluated on the following criteria:
1) Education and previous training
2) Relevance for the project
3) Publication and track record
4) Motivation.
This is an excellent opportunity for an individual with experience in cellular and molecular biology and dedication to cancer research. |
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Form of employment:
Fixed term employment with possibility to extension |
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Contact persons
Professor Galina Selivanova
+46 8 524 863 02
Galina.Selivanova@ki.se
Union representatives:
Anders Örn, SACO
Anders.Orn@ki.se
Torbjörn Laggar, ST
+ 46 8 524 862 12
Torbjorn.Laggar@ki.se
Gunnar Stenberg, SEKO
+46 8 524 880 75
Gunnar.Stenberg@ki.se |
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Please send your application, marked with reference number 1177/2012-226, to reach us by no later than March 6 2012 to Lina.rejno@ki.se. The following documents must be submitted with your application, and written in English:
1. A full CV, including date of public defense, title of thesis, previous academic appointments, academic title, current position, academic distinctions and committee work, two letters of reference
2. A full publication list
3. A cover letter stating your qualifications and a description of future research interests and scientific goals (max 2 pages).
4. Certificates testifying to sickness, service in the total defense, positions of trust in trade union organizations and student organizations, parental leave or similar circumstances
5. Verification from the Dissertation Committee or equivalent body (only if you are planning to defend your thesis within three months after the application deadline)
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See Karolinska Institutet´s homepage at http://ki.se/qualificationsportfolio for information about the qualification portfolio.
Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule. |
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| Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We therefore particularly invite women to apply for this position. We also value the qualities that ethnic and cultural diversity can contribute to the university. |
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The Department of Microbiology, Tumor and Cell Biology (MTC) is engaged in
research and education in the fields of immunology, infection-, cell- and tumor biology. MTC,
located at the Solna Campus of Karolinska Institutet, has about 230 employees and 140 PhD
students in approximately 34 research groups.
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Karolinska Institutet is one of the world´s leading medical
universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.
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